Bone pain is a rare disease. Despite the location indicated by patients with sensations of bone pain, it often involves the surrounding structures, but rarely the bone itself. However, some diseases really are responsible for bone pain. This is the case of fractures in direct trauma or fractures caused by fatigue (repeating the same gesture), bone tumors, or tumor metastases. Among other causes of bone pain are osteonecrosis, a bone tissue injury caused by an interruption of blood supply to the bone; and osteomyelitis, an infection of the bone or Paget's disease. X-rays are used to guide the diagnosis.