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Parkinson's disease progression - Definition


Parkinson's disease is a degenerative disease described as the progressive destruction of certain brain neurons that are responsible for producing dopamine, resulting in typically described symptoms of resting tremor, slowed movement, and stiffness of the muscles, called plastic rigidity. The disease progression is marked by early stages where only one side of the body is affected, then both, with the condition progressively worsening. Medication nevertheless helps to slow the disease progression, but also alters it. Initially there is a first stage called the "honeymoon period" where treatments alleviate symptoms, followed by a second stage where problems caused by the dopamine-based molecules appear with fluctuating efficiency, rendering treatment difficult to adequately adapt, then comes the final stage where more significant disorders appear with walking difficulties, cognitive disorders, and patients becoming bed-ridden.