Creatinine clearance - Definition

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Definition


Creatinine is a substance produced from the breakdown of creatin in muscle cells. It is essentially no more than organic waste, which must normally be expelled through urination after passing through the kidneys. In medicine, however, it is very useful in evaluating the elimination functions carried out by the renal glomerules. Glomerular filtration rate, or GFR, is estimated by calculating the clearance of creatinine depending on the levels of creatinine in the blood (serum creatinine), but also of the age, sex, and weight of the individual. Two formulas are commonly used: the Cockroft-Gault formula and the MDRD formula, which is more reliable in particular cases, such as in elderly subjects. There is no value that is too high for clearance, but under 60 milliliters per minute, there is the possibility of renal deficiency.