Creatinine clearance - Definition

Ask a question


The clearance of a molecule in medicine defines the treatment capacity of the molecule by an organ. This term is mostly used for creatinine, a substance produced by the muscles and removed by the kidneys in urine. This calculation is made from levels of creatinine in the plasma (serum creatinine), and assesses the functions of filtration and purification of the kidney with two formulas, the Cockcroft and MDRD; the older the patient, the more reliable the result. The creatinine clearance is decreased in patients with kidney failure and its level is related to the severity of the failure.