Elevated CPK - Definition

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Normal blood levels of the enzyme CPK (creatine phosphokinase) are generally very low and are only present in large quantities in the blood in cases of muscle damage. Several reasons can explain a higher rate of CPK, such as increased physical effort before the blood test or the use of certain medications including lipid-lowering statins. But a high level of CPK can also reveal more serious problems: in case of injury to the cardiac muscle, myocardial infarction, CPK MB levels rise within 3 hours after the onset of ischemia which is a sign of myocardial necrosis. CPK also increases in the blood in cases of rhabdomyolysis, a phenomenon due to the destruction of part of the muscle cells.