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Creatine Phosphokinase - Definition


Creatine phosphokinase (CPK), now more often called Creatine Kinase (CK), is an enzyme used exclusively by muscle cells to allow the functioning of muscles. CPK concentration is usually very low in the blood and its presence in abnormal quantities is indicative of the destruction (lysis) of muscle cells. This increase is seen in cases of rhabdomyolysis, lysis in voluntary control muscles, but also in cases of myocardial infarction. The main forms of CPK CPK-MB (or CK-MB) for the cardiac cells, CK-MM (or CK-MM) for the muscle cells and CPK-BB (or CK-BB) for brain cells .