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Transferrin - Definition


Definition


Transferrin is a protein found in the blood that primarily serves to transport iron around the body. It is a modulator, and is able to readjust the amount of iron circulating in the blood depending on the needs of the body. Usually only a third of the transferrin in the blood circulates bound to a molecule of iron. The concentration of an indicator called transferrin saturation (TSAT), an assessment of the percentage of transferrin bound to iron in a blood sample, can therefore reveal the amount of iron present in the body. If this level decreases, other conditions can be suspected, notably hemochromatosis, a significant overload of iron in the body caused by a genetic anomaly.
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