Cryoglobulinemia - Definition

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Cryoglobulinemia, when it is type II or III, is a pathology whose principal manifestations are purpura (appearance of red patches on the skin), joint pains, and asthenia (weakness and generalized fatigue). Cryoglobulinemia remains a relatively rare disease that affects around one person in 100,000 and mainly women. It may be accompanied by numerous other symptoms such as disorders of the liver (chronic hepatitis), the kidneys (glomerulonephritis), neurology (neuropathy), and blood vessels (vasculitis). Type I cryoglobulinemia, however, is often asymptomatic.