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Diabetes insipidus - Definition


Diabetes insipidus is a disease characterized by a deficiency of the kidneys that are unable to retain water. The cause is a hormonal disorder that can either come from the brain by the partial or complete absence of secretion by the pituitary anti-diuretic hormones or ADH, or from a maladaptive response of the kidney to the hormone. The disease is characterized by intense thirst and the expulsion of a large amount of low concentrated urine. The diagnosis is confirmed by a blood test and a urine test and the difference between a primary or secondary cause is made by a water deprivation test, or using an ADH injection.