Hemoglobin electrophoresis - Definition

Ask a question


Electrophoresis is a process that aims to separate different particles according to their electrical charge, size, and shape. This separation is accomplished by an electrical field generated by electrodes, brought into contact with the test solution. A hemoglobin electrophoresis is performed from a blood sample and will separate the different types of hemoglobin in the blood. Indeed, blood hemoglobin exists in different varieties, mainly A1 usually representing 98% of the hemoglobin in adults, and A2. But there is usually a quantity of fetal hemoglobin in adults, and certain types of hemoglobin are associated with blood disorders called hemoglobinopathies, such as hemoglobin S in particular, responsible for sickle cell anemia, which alters the shape of red blood cells.