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Hypercalcemia - Definition


Hypercalcemia means an abnormally high concentration of calcium in the blood. It may be a side-effect of bone destruction called osteolysis responsible for the excessive discharge of bone calcium in the blood, which is possible especially in cases of myeloma, bone cancer, or bone metastases. It may also be due to a deregulation of overactive parathyroid glands . Drugs are also a possible cause of hypercalcemia, the most frequently involved are diuretics and vitamin D. It usually appears as a clinical syndrome with fatigue, loss of appetite and weight loss, digestive disorders with abdominal pain, nausea or vomiting, increased daily urine and thirst, decreased muscle strength and sometimes mental confusion. The amount of calcium confirms the diagnosis and in cases of extreme hypercalcemia, the risk of heart resonance with possible arrhythmia requires a treatment including rapid hydration and lowering calcium levels with a significant use of medications, such as bisphosphonates .