CML - Chronic myeloid leukemia - Definition

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Definition


Chronic myeloid leukemia (CML) is a disease which is part of the myeloproliferative disorders, diseases in developing tissue and bone marrow characterized by an abnormal proliferation of mature cells (which is what differentiates the myeloproliferative leukemias). This leukemia is rare and is the side-effect of a chromosomal abnormality. It affects adults around the age of 50. Symptoms appear late: anemia, infections, bleeding, enlarged spleen and liver. This is a serious leukemia, often fatal. The diagnosis is suspected in a blood sample with a very high increase in white blood cells, reinforced by an analysis of a sample of bone marrow taken from a puncture of the sternum, and confirmed by the detection of chromosomal abnormalities. Treatment depends on the stage and progression of the disease, ranging from bone marrow graft to chemotherapy.