Macrocytosis - Definition

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Macrocytosis is an abnormality in blood characterized by the presence of macrocytes, red cells, whose size and volume is increased. Macrocytosis is often associated with the presence of anemia, a decreased number of red blood cells which decreases oxygenation of organs and tissues. Symptoms may be those of anemia with fatigue, a pale complexion, increased heart rate, dizziness, shortness of breath... It may be due to a deficiency of vitamin B12 or folate, vitamin B9, which causes a defect in the formation of red blood cells which become larger. Vitamin B12 or folate supplements, in this case, can handle macrocytosis. Macrocytosis is also observed in chronic alcoholism, in certain abnormalities in the bone marrow, or due to certain medications.