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Berger's disease - Definition


Definition


Berger's disease is a rare autoimmune disease that affects the kidneys. It is sometimes called Immunoglobulin A nephropathy, as it is characterized by the production of an antibody, immunoglobulin A, which is deposited in the portion of the kidney that filters waste, the glomerulus. It is frequently found in young adults after seeing red in the urine. The main symptoms of Berger's disease are hematuria, blood in the urine, and sometimes back pain. A strip test will confirm the presence of blood, but often also that of proteins. A renal biopsy can be done to confirm the diagnosis, but is often not necessary. Berger's disease may progress to severe renal insufficiency, which can cause death if a transplant cannot be done. There is currently no treatment for Berger's disease, but protective kidney treatments enable the partial control of the progression of the disease.
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