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Neuromuscular disease - Definition


A neuromuscular disease is a disease that affects the muscles and causes movement disorders. The disease may affect the nerves innervating these muscles or be a disorder at the neuromuscular junction, an area where nerve information is transmitted to the muscle cells. There is a very wide variety of neuromuscular diseases which may be genetic or side-effects of other infections, metabolic diseases, or the ingestion of toxic substances. The symptoms and consequences are thus very different depending on the affected muscles, and treatments, when they are possible, are divergent. Examples of neuromuscular diseases include myopathies, peripheral neuropathy including diabetic neuropathy, and amyotrophic diseases.